Many media sources have reported that when taken at bedtime, blood pressure pills work better, reducing the risk of heart attack and early death.
It follows a large trial conducted through northern Spain general practices. It included about 20,000 people with high blood pressure (age 60 on average).
Half the people were told at bedtime to take their blood pressure tablets, and the other half at waking. These were followed up for an average of 6 years, during which time about one in ten suffered a heart attack, heart failure or stroke, or died from cardiovascular disease.
The study found that people who take their blood pressure tablets at bedtime the night blood pressure was significantly lower and 45% less likely to have one of these results.
The trial lend support past studies with similar findings. However, the trial just analysed Spaniards from white ethnic backgrounds. It also does not look at the effects of time on a certain blood pressure tablets. Therefore, as the researchers say, more studies are needed before we see whether the advice on how to take blood pressure medication should be changed.
Unless you are taking diuretics (water tablets), which may mean you have to get up a lot at night to urinate, there should be no negative effects from taking them at night. But it might be worth talking to the GP before making changes in how you take your medications, especially if you take several different medications.
This study was conducted by researchers from the University of Vigo and several other institutions in Spain. This project received financial support from the Spanish government and several other organizations.
The study was published in the peer-reviewed open European Heart Journal and is available for online access.
British media coverage of this study was widely accurate.
This was a randomized controlled trial aimed to see whether it is better to take blood pressure tablets at bedtime or in the morning. A randomized trial is the best way to see the effectiveness of treatment for randomization have to balance differences in patient characteristics, such as health and lifestyle, which could affect the outcome.
One slight limitation is that the open-label trial (not blind) means patients and researchers are aware when they are taking their tablets.
An ideal design may have provided all the patients tablet morning and night, one set into the other drug and matching placebo (dummy tablets). However, the length of this trial will be extremely difficult. There could also be the risk of error (for example, patients taking placebo tablets 2 sets of the day and there is no cure them).
The trial was conducted between 2008 and 2018 in 40 general practices in northern Spain. This includes adults diagnosed with high blood pressure (hypertension) in accordance with the standards and criteria prescribed one or more blood pressure medications.
They recruited a total of 19 084 patients (mean 60 years, 56% male) who were told to take their medication at bedtime or in the morning. About a quarter of all patients recruited had type 2 diabetes, 43% were obese, 15% were smokers and 10% already have a past cardiovascular events such as heart attack. Patients wear different types of blood pressure medications.
Patients were followed up with clinical assessment at least once a year, which included blood tests and wore blood pressure monitors for 48 hours (ambulatory blood pressure monitoring). The main outcome of interest is the patients who experienced one or more:
They adjusted their analysis for the patient’s age, sex, cholesterol, initial blood pressure, smoking, diabetes and kidney disease.
During an average follow-up of 6 years, in 1752 adults (9%) had a major cardiovascular outcomes.
Patients who take their blood pressure tablets at bedtime had a 45% lower risk of any of these events (hazard ratio [HR] 0.55, 95% confidence interval [CI] 0.50 to .61). The researchers also found a decreased risk when they see each of the individual outcomes, such as heart attack or stroke.
Results of 48-hour blood pressure monitoring showed that patients taking their tablets at bedtime had lower blood pressure at night. There was no difference in daytime blood pressure between the two groups.
There was no difference between the groups in any of the side effects of treatment. There was also no difference in how many patients do not take their tablets should be, or when they should.
The researchers concluded that drug-taking blood pressure on sleep results in improved control of blood pressure “and, most importantly, markedly reduced the occurrence of major cardiovascular disease events”.
It is a worthwhile experiment to investigate the best time to take blood pressure medication. It has certain powers of a very large sample size and long duration of follow-up, which is quite rare for a randomized trial.
They found that taking the medication at bedtime lowers blood pressure at night and reduce the risk of heart attacks and other cardiovascular events. They found these differences not only when looking at all the combined event, but each individual. This suggests that when you take the drugs makes a real difference. This lends support to previous trials that have had similar findings.
There are currently a variety of blood pressure medications do not have a strict prescription information at the time of the day they need to be taken, with the exception that diuretics (water tablets) are often taken in the morning to avoid the need to urinate frequently at night.
Despite the positive findings, there are some limitations to the trial. These include that the researchers were not able to analyze the effect of time for individual anti hypertensives. Also the study was held in mainly Spanish, exclusively white ethnic populations that may not be representative of other populations.
The researchers themselves acknowledge that their test results now need to be validated in other study populations. More conclusive findings might in the future lead to a change in the way anti hypertensives are prescribed.
Hermida RC, Crespo JJ, Domínguez-Sardiña M, et al.
Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial
European Heart Journal. Published online October 22 2019
For more on this topic, watch a great video by Dr. Paula Wright:
QRISK has been used in the general practice setting since 2007. It has been upgraded to QRISK 2. It is a 10 year cardiovascular risk tool. There is a proposal to upgrade to a newer version of the algorithm called QRISK 3. This has been outlined in a recent paper published by Julia Hippisley-Cox, professor of clinical epidemiology and general practice1,Carol Coupland, professor of medical statistics in primary care and Peter Brindle, evaluation and implementation theme lead, NIHR CLAHRC West. The paper was published in the 23rd May 2017 issue of the BMJ. BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2099
Currently QRISK 2 includes the ages of 25 to 84 and includes
QRISK 3 will include the following additional factors:
Overall the calculator performed as the previous version. The new added risk factors were found to increase risk by about 10%, the only exception being HIV/AIDS.
You can use the new risk calculator here: https://qrisk.org/three/
The new 2017/18 Qof with the frailty index does away with the bureaucratic unplanned admissions direct enhanced service and replaces it with indentifying and managing the over 65s with moderate to severe frailty.
The electronic Frailty Index (eFI), which has been developed by the University of Leeds, TPP (System One), Bradford Teaching Hospitals NHS Foundation Trust, Bradford University and Birmingham University, is an evidence based criteria for identifying frail patients.
It is based upon 36 deficits comprising 2000 Read codes . The score is strongly predictive of adverse outcomes and has been validated in large international studies.
The eFI score is out of 36. For example if 9 deficits are present then the socre will be (9/36) or 0.25. In this way the following frailty categories can be defined:
|0 – 0.12||Fit|
|0.13 – 0.24||Mild Frailty|
|0.25 – 0.36||Moderate Frailty|
|> 0.36||Severe Frailty|
For those patients identified as living with severe frailty, practices should provide a clinical review, which should include an annual medication review and, where appropriate, discuss whether the patient has fallen in the last 12 months. Any other clinically-relevant intervention should also be provided. In addition, where a patient does not already have an enriched Summary Care Record (SCR) the practice will promote this seeking informed patient consent to activate the enriched SCR.
Wikipedia defines Upselling as a sales technique whereby a seller induces the customer to purchase more expensive items, upgrades or other add-ons in an attempt to make a more profitable sale.
We believe that the whole revalidation industry that has sprouted out of nowhere is at its core built on upselling. If it were up us at GP Tools, we would provide this toolkit completely free to our users. Unfortunately, in the post-truth world that we live in, offering something for free implies a catch somewhere down the road or some other negative connotation.
Which is why we are not surprised when we receive emails from Doctors’ who have been somehow manaevred into buying unnecessary add-ons from other toolkit providers.
Our company ethos at it’s most basic level prevents us from engaging in predatory business practices such as upselling. Nowhere on the site will you ever be bombarded with messages forcing you to take out a learning module subscription, nor will we ever email you anything similar.
Due to guidance from the GMC and the revalidation survey carried out this year which is finally coming to a conclusion, the vast majority of Royal College’s have updated the requirements for revalidation. Because of the underlying tone of revalidation being seen as an onerous activity detracting from patient care, the criteria have been relaxed. It seems that most UK doctors are unaware of these updated points and in fact talking to appraiser’s regularly it seems that they are as well.
For GPs, the RCGP has published a very useful document called RCGP Revalidation Mythbusters , in which the following key changes are worth mentioning. It should be pointed out that the revalidation requirements have been considerably downgraded after feedback from the GMC and RCGP revalidation survey.
Current revalidation myths, in order of importance (these are all FALSE).
The RO has no mandate to force upon doctors any particular toolkit. If your RO or local appraisal team is bullying or coercing you into using a particular legacy commercial toolkit then you are within your rights to make a formal complaint about the RO to the national revalidaiton support team at:
You can now claim as many credits for subsequent hours of work that you think have made an impact. e.g. if doing a search and implementing protocols took you 3 hours then 3 credits can be claimed regardless of how much time the initial learning activity took.
No longer a requirement. Events that caused no harm to patients should be documented under an alternatvie category.
Transformed into QIAs, case reviews, patient journeys, reflection on how to improve patient care, and how you are providing patient care.
Unfortunately this is not the case, and a recent court case demonstrated that your appraisal reflections can be used against you if a complaint has been taken to court. Trainee’s portfolio ‘used as evidence against them’ in legal case.
The RCGP recommends that your portfolio of supporting information should include all the core elements required by the GMC in a format that is professionally presented, typed so that it is legible, and capable of being transmitted electronically.
NHS England clearly says that, while they require appraisals to be submitted electronically and not on paper, the individual GP should have a choice about which toolkit to use (medical-appraisal-policy-0415, page 15).
The following is a communication from the Londonwide LMCs to all London based GPs regarding freedom of appraisal toolkit choice (27 January 2016 – emphasis added).
As you will know, NHSE funding for the use of the Clarity appraisal toolkit has ceased. Although many of you will pay for and continue to use Clarity, we have been asked to remind you that, should you wish, there are alternative toolkits as well as the free downloadable MAG form.
There is no requirement in the regulations to use any particular vehicle for your appraisal, although it may remain convenient to you to use a toolkit with which you, your appraiser and the responsible officers are familiar.
We recommend that GPs intending to use an alternative inform their appraisers well before their next appraisal date, and check with any alternative supplier the mechanism for transferring previous appraisal data from Clarity.
Dr Michelle Drage FRCGP
With the recent changes in NHS funding for appraisal toolkits. It is now the respoonsibility of the individual doctor to pay for thier online appraisal and revalidation toolkit.
Common sense dictates that as doctors are going to be paying for their toolkit they should be able to choose whichever appraisal vehicle / toolkit they like – as long as it fulfils all the requirements.
This very helpful NHS guidance:
NHS England guidance on appraisal toolkit choice
clearly states :
‘Whichever vehicle you decide to use, you will be responsible for ensuring that your appraiser has access to your system and understands its functionality. You must also ensure that your appraisal information complies with the Medical Appraisal Guide and is available in a format that permits it to be uploaded to the RMS. In terms of this latter point, if your appraisal can be downloaded as a pdf or Word document, this will be acceptable.’
So you are free to use whatever appraisal toolkit you like. With a range of innovative features we feel that GP Tools should be your first choice. Our ‘easy as email’ approach and ability to fulfil all NHS England requirements make us the ‘go to’ vehicle for medical appraisals.